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Assertion : $UAA,\,UAG$ and $UGA$ terminate protein synthesis.

Reason : They are not recognised by $tRNA$.

AIIMS 2011,AIIMS 2014, Medium
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Synthesis of polypeptide terminates when a nonsense codon of $mRNA$ reaches the $A-$ site. There are three nonsense codons-$UAA, \,UAG$ and $UGA$. These codons are not recognised by any of the $tRNAs$. Therefore, no more aminoacyl $tRNA$ reaches the $A$ site. The $P-$ site $tRNA$ is hydrolysed and the completed polypeptide is released in the presence of a release factor.
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