Question
Differentiate between leading strand and lagging strand.
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S.No.
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Leading strand
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Lagging strand
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1.
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It is a replicated strand of DNA which grows continuously without any gap.
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The lagging strand is a replicated strand of DNA which is formed in short segments called discontinuous.
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2.
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It does not require DNA ligase for its growth.
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DNA ligase is required for joining okazaki fragments.
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3.
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The direction of growth of a leading strand is 5' → 3'.
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The direction of the lagging strand is 3' → 5'.
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4.
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Only a single RNA primer is required.
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Starting of each okazaki fragment requires a new RNA.
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5.
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Its template opens in 3' → 5' direction.
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Its template opens in 5' → 3' direction
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6.
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Formation of leading strand begins immediately at the beginning of replication
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Formation of lagging strand begins a bit later than that of leading strand.
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