Question
Differentiate between Mendelian disorders and chromosomal disorders.
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S.No
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Mendelian disorders
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Chromosomal disorders
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1.
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Mendelian disorders are due to alteration or mutation in a single gene.
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Chromosomal disorders are those caused due to absence or excess presence of one or more chromosome(s) or abnormal arrangement of one/more chromosome(s).
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2.
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They are transmitted to the progeny in the same way as Mendelian principles of inheritance.
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They are not transmitted as the affected individual is sterile.
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3.
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The pattern of inheritance can be traced in a family tree by pedigree analysis, e.g. Phenylketonuria, Colourblindness.
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The disease can be confirmed by karyotyping, e.g. Down's syndrome, Turner's syndrome.
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