Question
Differentiate between rough and smooth endoplasmic reticulum. How is endoplasmic reticulum important for membrane biogenesis?

Answer

The major differences between rough and smooth endoplasmic reticulum are:
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
$SER$ has no ribosomal particles on the surface, hence look smooth.
$RER$ has particles of ribosome on the surface, therefore are rough in texture.
It helps in manufacturing of lipids and fat molecules.
They are the sites of protein synthesis.
Endoplasmic reticulum synthesises lipids (smooth endoplasmic reticulum) and proteins (rough endoplasmic reticulum) which are responsible for formation of membrane. Thus, they help in membrane biogenesis.

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