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$I$. In the absence of adenosine deaminase enzyme, purine metabolism is disturbed and $T-$lymphocytes fails to function $II$. $ADA$ deficiency is caused by the deletion of the gene for $ADA$
$III$. In some cases, it can be cured by bone marrow transplantation and enzyme replacement therapy. But in both approaches, the patients are not completely cured
$IV$. For permanent cure, genes isolated from the bone marrow cells producing $ADA$ at early embryonic stages can be a possible cure
Which of the above statements are correct?
$I.$ Haemophilia is a sex-linked recessive disease
$II.$ Down's syndrome is due to aneuploidy
$III.$ Phenylketonuria is an autosomal dominant gene disorder
$IV.$ Phenylketonuria is an autosomal recessive gene disorder
$V.$ Sickle cell anaemia is an $X$-linked recessive gene disorder