Question
For question, two statements are given-one labelled Assertion and the other labelled Reason. Select the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
  1. Both assertion and reason are true, and reason is the correct explanation of assertion.
  2. Both assertion and reason are true, but reason is not the correct explanation of assertion.
  3. Assertion is true, but reason is false.
  4. Both assertion and reason are false
Assertion: UAA, UAG and UGA terminate protein synthesis.
Reason: They are not recognised by tRNA.

Answer

  1. Both assertion and reason are true, and reason is the correct explanation of assertion.

Explanation:

Synthesis of polypeptide terminates when a nonsense codon of mRNA reaches the A-site. There are three nonsense codons- UAA, UAG and UGA. These codons are not recognised by any of the tRNAs. Therefore, no more aminoacyl tRNA reaches the A-site. The P-site tRNA is hydrolysed and the completed polypeptide is released in the presence of release factor. Thus termination occurs.

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