Maharashtra BoardEnglish MediumSTD 12 ScienceBIOLOGYMolecular Basis of Inheritance4 Marks
Question
Friedrich Miescher’s nuclein
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Answer
Nuclein is an acidic substance, having high phosphorus content and it was isolated by Friedrich Miescher in 1869, from the nuclei of pus cells.
As Nuclein had acidic properties and it was isolated from nucleus, it was called as nucleic acid.
E Miescher started working with white blood cells (the major component of pus). He used a salt solution to wash the pus off the bandages. He lysed the cells by adding a weak alkaline solution and isolated nucleic acid from nuclei that precipitated out of the solution.
By the early 1900s, it was known that Miescher’s nuclein was a mixture of proteins and nucleic acids (DNA and RNA).
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