Question
How can phenol be converted to aspirin?
✓
Answer
Phenol is converted into salicylic acid.
The reaction is usually carried out by allowing sodium phenoxide to absorb carbon dioxide and then heating the product to $400K$ and $4-7$ atm pressure. First unstable intermediate is formed which undergoes a proton shift to form sodium salicylate. The subsequent acidification of sodium salicylate gives,
Then aspirin is obtained by acetylating salicylic acid with acetic anhydride and cons. $H_2SO_4.$
The reaction is usually carried out by allowing sodium phenoxide to absorb carbon dioxide and then heating the product to $400K$ and $4-7$ atm pressure. First unstable intermediate is formed which undergoes a proton shift to form sodium salicylate. The subsequent acidification of sodium salicylate gives,
Then aspirin is obtained by acetylating salicylic acid with acetic anhydride and cons. $H_2SO_4.$
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