Question
How does inbreeding depression set in? Mention the procedure you would suggest to reverse this.

Answer

A disadvantage of inbreeding is that it results in the reduction of fertility and productivity. That means it causes inbreeding depression.
Inbreeding depression can be eliminated by mating the cattle within the same breed but, having no common ancestors for 4-6 generations. A single outcrossing can overcome inbreeding depression.

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