Question
Patient suffering from hypothyroidism shows increased level of $\text{TSH}$. Why?

Answer

  1. Hypothyroidism means decrease in the secretion of $T_3$ and $T_4$
  2. Decrease in $T_4, i.e$. thyroxine in the blood triggers negative feedback mechanism.
  3. The hormone receptors in hypothalamus detect this change and secrete $\text{TRE}$
  4. $\text{TRF}$ stimulates the pituitary to secrete $\text{TSH}$
  5. Thus, Patient suffering from hypothyroidism shows increased level of $\text{TSH}$ due to negative feedback control.

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