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STD 12 - 4. principal of inheritance and variation — Biology STD 12 Science — Question

CBSE BoardEnglish MediumSTD 12 ScienceBiologySTD 12 - 4. principal of inheritance and variation1 Mark
MCQ
Sickle cell anaemia is
  • A
    An autosomal linked dominant trait
  • ✓
    Caused by substitution of glutamic acid by valic acid in the $\beta$-globin chain of haemoglobin
  • C
    Caused by a change in $3$ base pairs of $DNA$
  • D
    Characterized by elongated sickle like $RBCs$ with a nucleus
✓

Answer

Correct option: B.
Caused by substitution of glutamic acid by valic acid in the $\beta$-globin chain of haemoglobin
b
Sickle cell anaemia is caused by a change in a single base pair of DNA. It is an autosomal recessive genetic disease reported from Negroes. In sickle cell haemoglobin the glutamic acid in beta haemoglobin chain is replaced by valine.

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