MCQ
Sickle cell anemia is caused by:
- AComplete absence of the haemoglobin gene
- BPoint mutation of the haemoglobin gene
- CIncreased affinity of haemoglobin for oxygen
- DTruncation of the haemoglobin protein
✓
Answer
- Point mutation of the haemoglobin gene
Explanation:
Hemoglobin has four protein subunits, two α-globin and two β - globin. The Hbb gene codes the β chain. A missense mutation, replacement of A by T at the 17th nucleotide of the Hbb gene changes the codon GAG (glutamic acid) to GTG (which encodes valine).
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