Statements related to human Insulin are given below. Which statement(s) is/are correct about genetically engineered Insulin?
$(a)$ Pro-hormone insulin contain extra stretch of C-peptide
$(b)$ A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted and combined by creating disulphide bond between them.
$(c)$ Insulin used for treating Diabetes was extracted from Cattles and Pigs.
$(d)$ Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone.
$(e)$ Some patients develop allergic reactions to the foreign insulin.
Choose the most appropriate answer from the options given below: