MCQ
The chemiosmotic coupling hypothesis of oxidative phosphorylation proposes that adenosine triphosphate $(ATP)$ is formed because
  • a proton gradient forms across the inner membrane
  • B
    there is a change in the permeability of the inner mitochondrial membrane toward adenosine diphosphate $(ADP)$
  • C
    high energy bonds are formed in mitochondrial proteins
  • D
    $ADP$ is pumped out of the matrix into the intermembrane space.

Answer

Correct option: A.
a proton gradient forms across the inner membrane
a
(a) : The chemiosmotic coupling hypothesis of oxidative phosphorylation proposed by Mitchell, explains the process of $ATP$ formation and states that it is linked to development of a proton gradient across a membrane. $ATP$ synthase, required for $ATP$ synthesis is located in $F_1$ particles present in the inner mitochondrial membrane and becomes active only when there is high concentration of proton on $F_0$ side as compared to $F_1$ side. The flow of proton through $F_0$ channel induces $F_1$ particle to function as $ATP$ synthase and the energy of proton gradient produces $ATP$ by attaching a phosphate radical to $ADP.$

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