The relative reactivities of acyl compounds towards nucleophbstitution are in the order of
  • Aacyl chloride $>$ acid anhydride $>$ ester $>$ amide
  • Bester $>$ acyl chloride $>$ a mide $>$ acid anhydride
  • Cacid anhydride $>$ amide $>$ ester $>$ acyl chloride
  • Dacid chloride $>$ ester $>$ acid anhydride $>$ amide
AIIMS 2018, Medium
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