Question
The schematic representation given below shows a DNA strand and two types of mutations in the DNA strand.
Image
(i) Identify the type of mutation exhibited in I and II.
(ii) Which of the above mutation is more harmful? Give reason.

Answer

(i) I is point mutation; II is Frame shift
(ii) Il as more codons are affected;
It is extremely likely to lead to large-scale changes to polypeptide length and chemical composition/ resulting in a non-functional protein that often disrupts the biochemical processes of a cell/Incorrect amino acids are inserted/ often premature termination occurs when a nonsense codon is read/ Frameshifts have very severe phenotypic effects.

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