Question
Types of mutations.
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Answer
- Chromosomal mutations : Loss (deletion) or gain (insertion/duplication) of a segment of DNA results in alteration in the chromosome.
- Point mutations : They involve change in a single base pair of DNA. E.g. Mutation that results in Sickle-cell anaemia.
- Deletion or insertion of base pairs of DNA : It causes frame-shift mutations or deletion mutation.
- Insertion or deletion of one or two bases changes the reading frame from the point of insertion or deletion.
- Insertion or deletion of three or multiples of three bases (insert or delete) results in insertion or deletion of amino acids and reading frame remains unaltered from that point onwards.
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