What are the causes of Down’s syndrome? - Vidyadip

Question

What are the causes of Down’s syndrome?

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Answer

Down’s syndrome is caused due to aneuploidy.
Aneuploidy is due to non-disjunction of chromosome at the time of gamete formation during meiosis. Due to non-disjunction, chromosomes fail to separate.
In addition to a homologous pair of 21st chromosome there is an extra 21st, therefore it is called trisomy (2n + 1) of 21st chromosome.

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