Question
  1. What is a phosphodiester bond?
  2. Explain competitive inhibition by giving an example.

Answer

  1. Phosphodiester bond: It is the bond in a nucleic acid (polynucleotide), which links the 3' carbon of the sugar of one nucleotide to the 5' carbon of the sugar of another nucleotide; as there is an ester bond on either side of the phosphate moiety, it is called a phosphodiester bond.
  2. Competitive inhibition: It is the phenomenon is which the inhibitor closely resembles the substrate in its molecular structure and competes with the substrate for the active site (substrate-binding site) on the enzyme; the enzyme activity declines, e.g. inhibition of succinic dehydrogenase by malonate.

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