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Molecular Basis of Inheritance — BIOLOGY STD 12 Science — Question

Maharashtra BoardEnglish MediumSTD 12 ScienceBIOLOGYMolecular Basis of Inheritance3 Marks
Question
Why are Okazaki fragments formed on lagging strand only?
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Answer

  1. The lagging template is the template strand with free 5’ end.
  2. The replication always starts at C-3 end of template strand and proceeds towards C-5 end.
  3. Both the strands of the parental DNA are antiparallel and new strands are always formed in 5′ → 3′ direction, i.e. DNA polymerase synthesizes new strand in only one direction i.e. 5′ → 3′ direction.
  4. Hence, the lagging templates becomes available for replication only discontinuously in small patches.
  5. The new lagging strand develops discontinuously away from the replicating fork in the form of small Okazaki fragments.
  6. Hence, Okazaki fragments formed on lagging strand only.

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