Principles of Inheritance and Variation — BIOLOGY STD 12 Science — Question
Maharashtra BoardEnglish MediumSTD 12 ScienceBIOLOGYPrinciples of Inheritance and Variation1 Mark
Question
Why do normal red blood cells become elongated sickle shaped structures in a person suffering from sickle cell anaemia?
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Answer
The defect is caused by the substitution of glutamic acid by valine at the sixth position of the beta globin chain of haemoglobin. The mutant molecule undergoes polymerisation under low O, tension causing the change in the shape.
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