→ Spermatogenesis starts at the age of puberty due to significant increase in the secretion of gonadotropin releasing hormone (GnRH). This is a hypothalamic hormone.
→ The increased levels of GnRH then act at the anterior pituitary gland and stimulate secretion of two gonadotropins - luteinising hormone (LH) and follicle stimulating hormone (FSH).
→ LH acts at the leydig cells and stimulates synthesis and secretion of androgens. Androgens, in turn, stimulate the process of spermatogenesis.
→ FSH acts on the Sertoli cells and stimulates secretion of some factors which help in the process of spermiogenesis.