Neurospora crassa is known as’Drosophila of Plant Kingd om’. Itisau sefulmodel organism as it can be easily cultured in laboratories due to simple life cycle and simple nutrient requirements. Neurospora crassa is the subject of intensive research leading to significant contributions. By using Neurospora mutants, Mary Mitchell reported the first example of gene conversion. Barbara McClintock, famous for her work in transposition, showed for the first time, that fungal chromosomes were typically eukaryotic using it. Further, several aspects of metabolism and cytogenetic were first studied in it. The first sequencing of a mitochondrial nucleic acid came from this fungus and self-splicing of a mitochondrial intron was demonstrated for the first time. Neurospora also made significant contributions to the study of the mechanisms underlying protein import into mitochondria. Moreover, mitochondrial plasmids were discovered and characterized. It has also been important in areas of biological research, including recombination, DNA repair, differentiation, morphogenesis and cell biology, and notably, DNA methylation and silencing, findings applicable not only to the fungi, but to other eukaryotes as well.