- $\frac{4}{3}$
Solution:

Let a be the length of an edge of the cube and let one corner be at the origin as shown in the figure. Clearly, OP, AR
The direction ratiosm of OP, AR, BS and CQ are
a - 0, a - 0, a - 0, i.e. a, a, a
0 - a, a - 0, a - 0, i.e. -a, a, a
a - 0, 0 - a, a - 0, i.e. a, -a, a
a - 0, a - 0, 0 - a, i.e. a, a, -a
Let the direction ratios of a line be proportional to l, m and n. Suppose this line makes angles $\alpha,\beta,\gamma$ and $\delta$ with OP, AR.
Now, $\alpha$ is the angle between OP and the line whose direction ratios are proportional to l, m and n.
$\cos\alpha=\frac{\text{a}.\text{l}+\text{a}.\text{m}+\text{a}.\text{n}}{\sqrt{\text{a}^2+\text{a}^2+\text{a}^2}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}\Rightarrow\cos\alpha=\frac{\text{l}+\text{m}+\text{n}}{\sqrt{3}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}$
Since $\beta$ is the angle between AR and the line with direction ratios proportional to l, m and n, we get
$\cos\beta=\frac{-\text{a}.\text{l}+\text{a}.\text{m}+\text{a}.\text{n}}{\sqrt{\text{a}^2+\text{a}^2+\text{a}^2}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}\Rightarrow\cos\beta=\frac{-\text{l}+\text{m}+\text{n}}{\sqrt{3}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}$
Similarly,
$\cos\gamma=\frac{\text{a}.\text{l}-\text{a}.\text{m}+\text{a}.\text{n}}{\sqrt{\text{a}^2+\text{a}^2+\text{a}^2}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}\Rightarrow\cos\gamma=\frac{\text{l}-\text{m}+\text{n}}{\sqrt{3}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}$
$\cos\delta=\frac{\text{a}.\text{l}+\text{a}.\text{m}-\text{a}.\text{n}}{\sqrt{\text{a}^2+\text{a}^2+\text{a}^2}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}\Rightarrow\cos\delta=\frac{\text{l}+\text{m}-\text{n}}{\sqrt{3}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}$
$\cos^2\alpha+\cos^2\beta+\cos^2\gamma+\cos^2\delta$
$=\frac{(\text{l}+\text{m}+\text{n})^2}{3(\text{l}^2+\text{m}^2+\text{n}^2)}+\frac{(-\text{l}+\text{m}+\text{n})^2}{3(\text{l}^2+\text{m}^2+\text{n}^2)}+\frac{(\text{l}-\text{m}+\text{n})^2}{3(\text{l}^2+\text{m}^2+\text{n}^2)}+\frac{(\text{l}+\text{m}-\text{n})^2}{\sqrt{3}\sqrt{\text{l}^2+\text{m}^2+\text{n}^2}}$
$=\frac{1}{3(\text{l}^2+\text{m}^2+\text{n}^2)}\Big\{(\text{l}+\text{m}+\text{n})^2+(-\text{l}+\text{m}+\text{n})^2+(\text{l}-\text{m}+\text{n})^2+(\text{l}+\text{m}-\text{n})^2\Big\}$
$=\frac{1}{3(\text{l}^2+\text{m}^2+\text{n}^2)}4\big(\text{l}^2+\text{m}^2+\text{n}^2\big)=\frac{4}{3}$.