Question
Actin filament
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Answer
Actin filament: It is a complex type of contractile protein. It is made up of three components:
- F actin: It forms the backbone of actin filament. F actin is made up of two helical strands. Each strand is composed of polymerized G actin molecules. One ADP molecule is attached to G actin molecule.
- Tropomyosin: The actin filament contains two additional protein strands that are polymers of tropomyosin molecules. Each strand is loosely attached to an F actin. In the resting stage, tropomyosin physically covers the active myosin-binding site of the actin strand.
- Troponin: It is a complex of three globular proteins, is attached approx. 2/3rd distance along each tropomyosin molecule. It has affinity for actin, tropomyosin and calcium ions. The troponin complex is believed to attach the tropomyosin to the actin. The strong affinity of troponin for calcium ions is believed to initiate the contraction process.
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