$I$. Lymphocytes are obtained from the patients
$II$. Lymphocytes are transferred to the culture dishes
$III$. Lymphocytes are transfected with the normal $ADA$ genes
$IV$. The transfected cell are returned to the patients
The chronological order should be
Adenosine deaminase enzyme is very important for the immune system to function. In the absence of adenosine deaminase enzyme, purine metabolism is disturbed and $T-$lymphocytes fails to function. $ADA$ deficiency can lead to Severe combiuned Immune Deficiency $(SCID)$
$SCID$ is caused due to defect in the genes for the enzyme adenosine deaminase. The genetic diseases that are being investigated for gene therapy ranges from sickle-cell anaemia to Severe Combined Immuno Deficiency $(SCID)$. In some children, $ADA$ deficiency can be cured by bone marrow transplantation
However, in others it can be treated by the enzyme replacement therapy, in which functional $ADA$ is given to the patient by injection. But in both approaches, the patients are not completely cured. For permanent cure, gene isolated from the bone marrow cells producing $ADA$ at early embryonic stage can be a possible cure
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Match the following columns.
| Column $- I$ | Column $- II$ |
| $(a)$ Contraceptive pilll | $(1)$ Ejaculated semen would not enter into the female reproductive tract |
| $(b)$ Condom | $(2)$ Inhibit ovulation and implantation |
| $(c)$. Sterilsation | $(3)$ Increase phagocytosis of sperms |
| $(d)$ IUDs | $(4)$ Blocks gariete transport |
