Question
Describe various steps in urine formation.
✓
Answer
Urine formation involves three main processes namely:
Rate (GFR): The amount of the filtrate formed by the kidneys per minute is called glomerular filtration rate (GFR). GFR in a healthy individual is approximately $125 \mathrm{ml} /$ minute, ie., 180 litres per day. On an average, $1100-1200 \mathrm{ml}$ of blood is filtered by the kidneys per minute which constitute roughly $\frac{1}{5}$ th of the blood pumped out by each ventricle of the heart in a minute. Regulation of GFR. The kidneys have built-in mechanisms for the regulation of glomerular filtration rate. One such efficient mechanism is carried out by juxta glomerular apparatus (JGA). JGA is a special sensitive region formed by cellular modifications in the distal convoluted tubule and the afferent arteriole at the location of their contact. A fall in GFR can activate the JG cells to release renin which can stimulate the glomerular blood flow and thereby the GFR back to normal. Reabsorption: A comparison of the volume of the filtrate formed per day ( 180 litres per day) with that of the urine released ( 1.5 litres), suggest that nearly 99 per cent of the filtrate has to be reabsorbed by the renal tubules. This process is called reabsorption. The tubular epithelial cells in different segments of nephron perform this either by active or passive mechanisms. For example, substances like glucose, amino acids, $\mathrm{Na}^{+}$, etc., in the filtrate are reabsorbed actively whereas the nitrogenous wastes are absorbed by passive transport. Reabsorption of water also occurs passively in the initial segments of the nephron. During urine formation, the tubular cells secrete substances like $\mathrm{H}^{+} . \mathrm{K}^{+}$and ammonia into the filtrate. Tubular secretion is also an important step in urine formation as it helps in the maintenance of ionic and acid base balance of body fluids.
- Glomerular Filtration.
- Reabsorption.
- Secretion.
Rate (GFR): The amount of the filtrate formed by the kidneys per minute is called glomerular filtration rate (GFR). GFR in a healthy individual is approximately $125 \mathrm{ml} /$ minute, ie., 180 litres per day. On an average, $1100-1200 \mathrm{ml}$ of blood is filtered by the kidneys per minute which constitute roughly $\frac{1}{5}$ th of the blood pumped out by each ventricle of the heart in a minute. Regulation of GFR. The kidneys have built-in mechanisms for the regulation of glomerular filtration rate. One such efficient mechanism is carried out by juxta glomerular apparatus (JGA). JGA is a special sensitive region formed by cellular modifications in the distal convoluted tubule and the afferent arteriole at the location of their contact. A fall in GFR can activate the JG cells to release renin which can stimulate the glomerular blood flow and thereby the GFR back to normal. Reabsorption: A comparison of the volume of the filtrate formed per day ( 180 litres per day) with that of the urine released ( 1.5 litres), suggest that nearly 99 per cent of the filtrate has to be reabsorbed by the renal tubules. This process is called reabsorption. The tubular epithelial cells in different segments of nephron perform this either by active or passive mechanisms. For example, substances like glucose, amino acids, $\mathrm{Na}^{+}$, etc., in the filtrate are reabsorbed actively whereas the nitrogenous wastes are absorbed by passive transport. Reabsorption of water also occurs passively in the initial segments of the nephron. During urine formation, the tubular cells secrete substances like $\mathrm{H}^{+} . \mathrm{K}^{+}$and ammonia into the filtrate. Tubular secretion is also an important step in urine formation as it helps in the maintenance of ionic and acid base balance of body fluids.
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