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$I.$ Primary and secondary phloem gets crushed during secondary growth
$II.$ During secondary growth, primary xylem remains more or less intact
$\begin{array}{|p{0.45\linewidth}|p{0.45\linewidth}|} \hline Column\,\,-I & Column\,\,-II \\ \hline 1.\,\,\,1733\,\,-\,\,1804 & p.\,\,Jan\,\,Ingen\,\,house \\ \hline 2.\,\,\,1730\,\,-\,\,1799 & q.\,\,T.W\,\,Engelman \\ \hline 3.\,\,\,1897\,\,-\,\,1985 & r.\,\,Joseph\,\,Priestley \\ \hline 4.\,\,\,1843\,\,-\,\,1909 & s.\,\,Cornelius\,\,Van\,\,Niel \\ \hline \end{array}$
$(a)$ Pro-hormone insulin contain extra stretch of C-peptide
$(b)$ A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted and combined by creating disulphide bond between them.
$(c)$ Insulin used for treating Diabetes was extracted from Cattles and Pigs.
$(d)$ Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone.
$(e)$ Some patients develop allergic reactions to the foreign insulin.
Choose the most appropriate answer from the options given below: