Question
Germ line gene therapy and somatic cell gene therapy.
| Germ line gene therapy | Somatic cell gene therapy |
| 1. Germ line gene therapy involves modification of genome of germ cells like sperms, eggs, early embryos. | 1. Somatic cell gene therapy involves modification of genome of somatic cells like bone marrow cells, hepatic cells, fibroblasts, endothelium, pulmonary epithelial cells, central nervous system and smooth muscle cells of wall of blood vessels. |
| 2. It allows transmission of the modified genetic information to the next generation. | 2. It does not allow transmission of the modified genetic information to the next generation. |
| 3. Its application in human beings is not encouraged because of technical and ethical reasons. | 3. It is a feasible option and clinical trials are carried out for treatment of various diseases. |
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