Question
How are prosthetic groups different from cofactors?

Answer

Differences between prosthetic groups and cofactors are:
S. No
Prosthetic group
Cofactor
(a)
It is the non-protein part or the group which gets permanently attached to the enzyme.
It is the non-protein substance or group which gets attached to the enzyme, temporarily or permanently.
(b)
Prosthetic groups are organic factors, but some are metallic also like Iron, prophyrin of the cytochromes.
These can be organic, inorganic or metallic factors.

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