Question
How can phenol be converted to aspirin?
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Answer
Phenol is converted into salicylic acid. The reaction is usually carried out by allowing sodium phenoxide to absorb carbon dioxide and then heating the product to $400 K$ and $4-7$ atm pressure. The first unstable intermediate is formed which undergoes a proton shift to form sodium salicylate. The subsequent acidification of sodium salicylate gives.
Then aspirin is obtained by acetylating salicylic acid with acetic anhydride and conc. $H_2SO_4$
The preparation of Aspirin from salicylic acid is an example of an electrophilic substitution reaction in which carbon dioxide is an electrophile.
Then aspirin is obtained by acetylating salicylic acid with acetic anhydride and conc. $H_2SO_4$
The preparation of Aspirin from salicylic acid is an example of an electrophilic substitution reaction in which carbon dioxide is an electrophile.
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