For maintaining continuous culture system in bioreactors, they are continuously and regularly fed with the growth culture medium steadily, maintaining the appropriate temperature, pressure, pH and other parameters within the bioreactors. From the other end of the bioreactor, finished product generated as a result of microbial action is continuously or periodically withdrawn in specified amounts.
Continuous culture system is maintained in bioreactors because the cells can be maintained in a constant physiological state which ensures continuous and regular outflow of desired products from the bioreactor.