Question
Intrinsic and Extrinsic process of clotting.
✓
Answer
| Intrinsic process | Extrinsic process |
| 1. The intrinsic pathway requires only clotting factors found within the blood itself – in particular, clotting factor XII (Hageman factor) from the platelets. | 1. The extrinsic pathway is initiated by factors external to the blood, in the tissues adjacent to damaged blood vessel – in particular, it is initiated by clotting factor III, thromoboplastin from the damaged tissues. |
| 2. It is a longer, multistep process and it takes a little longer for the blood to clot by this mechanism. | 2. It involves fewer chemical reaction steps and produce a clot a little more quickly than the intrinsic pathway. |
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