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E. coli has only $4.6 \times 10^{6}$ base pairs and completes the process of replication within 18 minutes; then the average rate of polymerisation is approximately
Arrangement of $DNA$ has the triplet base sequence $AAC\ GAC\ AGC\ GGC\ ACA\ AAA$. Due to mutation, the first base only got deleted. Then the likely effect of this on the coding of the $DNA$ segment is that