$A$ : Polypeptide sequences are dictated by $DNA$ and represented by $mRNA$.
$R$ : Sequence of amino acids in a polypeptide can be predicted by the exact sequence of nucleotides on the $mRNA$ and template $DNA$
Medium
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$A$ : Operator gene is functional when it is not blocked by repressor.
$R$ : Regulator gene produces active protein only which acts on operon system in $E$.coli