Nodes are the points where the vibrating string can be touched without disturbing its motion.
When the string vibrates in its fundamental mode, the string vibrates in one loop. There are no nodes formed between the fixed ends. Hence, there are no point on the string which can be touched without disturbing its motion.
When the string vibrates in its first overtone (second harmonic), there are two loops of the stationary wave on the string. Apart from the two nodes at the two ends, there is now a third node at its centre. Hence, the string can be touched at its centre without disturbing the stationary wave pattern.
When the string vibrates in its second overtone (third harmonic), there are three loops of the stationary wave on the string. So, apart from the two end nodes, there are two additional nodes in between, at distances one-third of the string length from each end. Thus, now the string can be touched at these two nodes.