Question
Define the following as related to protein :
Primary structure
Primary structure
✓
Answer
(i) Primary structure of protein : In proteins one or more polypeptide chains are present. In each polypeptide of a protein, amino acids are linked in specific and definite sequence. The specific sequence of amino acids is called the primary structure of proteins. This sequence varies in different proteins. Frederick Sanger (1953) was the first to determine the primary structure of insulin secreted by the pancreas.
Among the various amino acids present in a particular protein, replacement of one $\alpha$-amino acid with another $\alpha$ amino acid changes or destroys biochemical reactivity of that protein. Example : Disease sickel cell anemia is caused when glutamic acid in hemoglobin is replaced by valine. The primary structure of proteins can be represented by following figure :
Among the various amino acids present in a particular protein, replacement of one $\alpha$-amino acid with another $\alpha$ amino acid changes or destroys biochemical reactivity of that protein. Example : Disease sickel cell anemia is caused when glutamic acid in hemoglobin is replaced by valine. The primary structure of proteins can be represented by following figure :
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