With the help of suitable diagrams, explain the mitosis in detail.
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(1) There are two stages of mitosis. These are
(a) Karyokinesis or nuclear division and
(b) Cytokinesis or cytoplasmic division. Karyokinesis takes place in further four phases, viz prophase, metaphase, anaphase and telophase.
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(a) Karyokinesis:
(i) Prophase: During prophase, condensation of chromosomes starts. The thin and thread like chromosomes start thickening. They are seen with their pair of sister chromatids. In animal cells the centrioles are seen to duplicate and move to opposite poles of the cell. Nuclear membrane and nucleolus disappear.

(ii) Metaphase: Chromosomes complete their condensation and each one is seen with its sister chromatids. The chromosomes are seen in equatorial plane of the cell. The spindle fibres are formed from polar region, where centrioles are present, and they attach themselves to the centromere of each chromosome. Nuclear membrane now disappears completely.

(iii) Anaphase: The centromeres of the chromosomes now divide forming two daughter chromosomes. The spindle fibres pull apart the chromosomes from equatorial region to the opposite poles. Chromosomes moving to the poles appear like bunch of bananas. One set of chromosomes reach each pole by the end of the anaphase.

(iv) Telophase: Telophase is reverse of events that occurred in prophase. The thickened chromosomes decondense. They again assume the thin and thread like appearance. Nuclear membrane and nucleolus appear again. The spindle fibres are completely lost. The cell looks as if it has two nuclei in one cytoplasm.

(b) Cytokinesis: In animal cells a notch develops in the middle of the cell. This notch goes on deepening down and later the cytoplasm divides into two. In plant cells, cell plate formation takes place and then cytokinesis takes place.

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